Menthol is a substance that causes a sensation of cold in humans. When it binds to certain receptors, their shape changes, allowing calcium to enter and triggering a nerve signal. The brain interprets this signal as a feeling of cold. This sensation does not reflect a real change in temperature but depends on a complex nerve interaction initiated by a single substance: menthol. These same receptors are responsible for sensing cold. As 'Science Alert' reports, the sudden sensation of cold in the mouth or on the skin is often associated with familiar, everyday products, from toothpaste to cough drops and topical creams. Menthol works by activating receptors known as TRPM8, which are located on nerve endings in the mouth and on the skin. This is why water or air feels colder after coming into contact with menthol.
