Recent research has identified genetic changes that may explain why orange juice consumption contributes to lowering blood pressure and improving heart health, as observed in previous studies. Scientists suggest that compounds like hesperidin, a flavonoid found in oranges, play a role in these positive effects through their antioxidant and anti-inflammatory properties. Recent studies indicate that regular consumption of orange juice may offer significant health benefits beyond basic nutrition. Responses vary among individuals; those with excess weight show greater changes in fat-related genes, while leaner volunteers exhibit a stronger effect on inflammation. This was reported by David C. Gaz, a lecturer in chemical diseases at the University of Westminster. A systematic review involving 639 participants concluded that regular juice consumption lowers insulin resistance and cholesterol levels, two key factors for heart health. Whole fruit remains preferable due to its fiber content, but a small glass of pure orange juice daily can contribute to accumulating positive effects that support health over time. Other studies have shown that juice improves vascular function, regulates blood sugar, and supports the gut microbiome by increasing bacteria that produce beneficial fatty acids for blood pressure. Although some studies suggest a limited impact on certain fats like triglycerides, the overall evidence supports the juice's benefits, particularly in reducing inflammation and improving long-term heart health markers. One study found that drinking 500 ml of pure juice daily for two months led to positive changes in the activity of thousands of genes in immune cells, especially those related to blood pressure control, inflammation, and sugar processing in the body. The results showed decreased activity in specific genes that typically increase under stress, such as NAMPT and IL6, as well as the SGK1 gene, which affects the kidneys' retention of salt.
